ABSTRACT
Wound infection is one of the most common problems in surgery and antibiotic usage is one of the ways to prevent it. This Study was performed for six months. All patients who were admitted for acute appendicitis in even days were given single dose of 500mg of metronidazole via IV route and all the patients who were admitted in the odd days were given single dose of 500mg metronidazole via IV route, plus two Separate doses of metronidazole in post operation period. There were 145 patient who were evaluated for this study with 115 male [%79.3] and 30 female [%20.7]. The first group [n=69] were received single dose of metronidazole where the second group [n=76] were received three doses of metronidazole. All patients had not any signs of wound infection. There weren't any meaningful statistical differences for prophylaxis of wound infection between single dose and multiple dose of antibiotic